Subchronic Toxicity of the Physalis minima Leaves

Setyawati Soeharto, Dian Nugrahenny, Nur Permatasari, Elly Mayangsari

Abstract


The study was to evaluate the subchronic toxicity of aqueous extract of Physalis minima leaves in female rats. Eighteen female Wistar rats were orally administered with aqueous extract of P. minima leaves at doses of 90, 270 and 450 mg/kg BW, respectively for 90 days. Six female rats without any treatment were provided as a control group. At the end of the experiment, blood samples were collected for hematological and biochemical (aspartate transaminase/AST, alanine transaminase/ALT, creatinine, urea, glucose, cholesterol, and triglyceride) analyses. The results showed that hematological and biochemical biomarkers were not significantly different in treated groups compared to the control group. It is concluded that the aqueous extract of P. minima leaves do not induce hematologic toxicity, hepatotoxicity and renal toxicity in the subchronic toxicity study.


Keywords


Physalis minima; sub chronic toxicity; rats

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References


Arsad, S.S., Esa, N.M., and Hamzah, H. 2014. Histopathologic changes in liver and kidney tissues from male Sprague Dawley rats treated with Rhaphidophora decursiva (Roxb.) Schott extract. J Cytol Histo, S4. http://dx.doi.org/10.4172/2157-7099.S4-001. https://www.omicsonline.org/open-access/histopathologic-changes-in-liver-and-kidney-tissues-from-male-sprague-dawley-rats-treated-with-rhaphidophora-decursiva-roxb-schott-extract-2157-7099.S4-001.php?aid=23879

Arthur, F.K.N., Wood, E., Terlabi, E.O., and Larbie C. 2011. Evaluation of acute and subchronic toxicity of Annona muricata (Linn) aqueous extract in animals. Euro. J. Exp. Bio, 1 (4): 115-124. http://www.imedpub.com/articles/evaluation-of-acute-and-subchronic-toxicity-of-iannona-muricatailinn-aqueous-extract-in-animals.pdf

Chothani, D.L. and Vaghasiya, H.U. 2012. A phyto-pharmacological overview on Physalis minima Linn. Indian Journal of Natural Products and Resources, vol. 3, no. 4, pp. 477–482. http://nopr.niscair.res.in/bitstream/123456789/15571/1/IJNPR%203(4)%20477-482.pdf

Desai, A.K., Grossberg, G.T. 2003. Herbals and botanicals in geriatric psychiatry. Am J Geriatr Psychiatry 11: 498-506. https://www.ncbi.nlm.nih.gov/pubmed/14506083

Kalsum, U., Ali, M., Widodo, M.A., Kalim, H. 2013. Effect of methanolic extract of Physalis minima on gastric inflammation and gastric ulcers formation. J Exp Integr Med; 3(4): 331-335. http://www.scopemed.org/?mno=37804

Lestari, B., Permatasari, N., Rohman, M.S. 2016. Methanolic extract of ceplukan leaf (Physalis minima) attenuate ventricular fibrosis through inhibition of TNF-𝛼 in ovariectomized rats, Advances in Pharmacological Sciences, Vol 2016, http://dx.doi.org/10.1155/2016/2428052 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752972/

Olson, H., Betton, G., Robinson, D., et al. 2000. Concordance of the toxicity of pharmaceuticals in humans and in animals, Regulatory Toxicology and Pharmacology, vol. 32, no. 1, pp. 56– 67. http://www.sciencedirect.com/science/article/pii/S0273230000913990?via%3Dihub

Perk, B.O., Ilgin, S., Atli, O., Duymus, H.G., and Sirmagul, B. 2013. Acute and subchronic toxic effects of the fruits of Physalis peruviana L. Evidence-Based Complementary and Alternative Medicine Volume 2013, http://dx.doi.org/10.1155/2013/707285. https://www.hindawi.com/journals/ecam/2013/707285/

Permatasari, N., Nurdiana, Setyawati. 2010. Effect non-genomic and genomic of extract leaf of Physalis minima in endothelial cells culture (HUVECs), Jurnal Ilmu- Ilmu Hayati: 22: 14-19. http://lppm.ub.ac.id/wp-content/uploads/2013/01/Nur-Permatasari.pdf

Verma, A.K. and Kumar, A. 2011. Therapeutic uses Withania somnifera (ashwagandha) with a note on withanolides and its pharmacological actions. Asian J Pharm Clin Res; 4 (11): 1-4

WHO. 2000. General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine. Geneva: WHO.

Wu, S.J., Tsai, J.Y., Chang, S.P., Lin, D.L., Wang, S.S., Huang, S.N., Ng, L.T. 2006. Supercritical carbon dioxide extract exhibits enhanced antioxidant and anti-inflammatory activities of Physalis peruviana, Journal of Ethnopharmacology 108; 407–413. http://www.sciencedirect.com/science/article/pii/S0378874106002893?via%3Dihub




DOI: https://doi.org/10.21776/ub.rjls.2018.005.01.8

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